Hoyin Chu

Hoyin Chu

Computational Biologist with background in computer science and mathematics. Interested in the application and development of computational methods to answer questions in cancer genomics.

Publications

This page features full-length papers where I am one of the authors. For conference abstracts see Abstracts

You can also find my papers on my Google Scholar profile.

# Denotes equal contributions

First / Co-first Author

Figure from “Sequence and structural determinants of efficacious de novo chimeric antigen receptors”
Sequence and structural determinants of efficacious de novo chimeric antigen receptors
Arthur Chow#, Hoyin Chu#, Ruofan Li, Benan N. Nalbant, Abdul Vehab Dozic, Laura C. Kida, Zeyu Tang, Joseph R. Palmeri, Caleb A. Lareau
Nature Biomedical Engineering  ·  Sep 2026
DOI
Figure from “Patient-partnered multiomics reveals the molecular architecture of angiosarcoma”
Patient-partnered multiomics reveals the molecular architecture of angiosarcoma
Hoyin Chu, Marissa Hollyer, Brittany A. Borden, Christopher R. Reilly, Jorge Gómez Tejeda Zañudo, …, Diane M. Diehl, Eliezer M. Van Allen, Nikhil Wagle, Corrie A. Painter, Saud AlDubayan
Nature Communications  ·  Jul 2026
DOI
Figure from “Interplay of Mendelian and polygenic risk factors in Arab breast cancer patients”
Interplay of Mendelian and polygenic risk factors in Arab breast cancer patients
Mohammed Al-Jumaan#, Hoyin Chu#, Abdullah Alsulaiman, Sabrina Y. Camp, Seunghun Han, Riaz Gillani, Yousef Al Marzooq, Fatmah Almulhim, Chittibabu Vatte, Areej Al Nemer, Afnan Almuhanna, Eliezer M. Van Allen, Amein Al-Ali, Saud H. AlDubayan
Genome Medicine  ·  Sep 2023
DOI
Profiling of pharmacogenomic variants in CYP2D6 and DPYD in indigenous Arab breast cancer patients
Abdullah Al-Sulaiman#, Hoyin Chu#, Mohammed Al-Jumaan, Mohammed Alyahya, Yousef Al Marzooq, Fatmah Almulhim, Chittibabu Vatte, Areej Alnimer, Afnan Almuhanna, Amein Al-Ali, Saud H. AlDubayan
Pharmacogenomics  ·  May 2023
DOI
Figure from “Using Association Rules to Understand the Risk of Adverse Pregnancy Outcomes in a Diverse Population”
Using Association Rules to Understand the Risk of Adverse Pregnancy Outcomes in a Diverse Population
Hoyin Chu, Rashika Ramola, Shantanu Jain, David M. Haas, Sriraam Natarajan, Predrag Radivojac
Pacific Symposium on Biocomputing  ·  2023
DOI
Figure from “The influence of genetic predisposition and physical activity on risk of Gestational Diabetes Mellitus in the nuMoM2b cohort”
The influence of genetic predisposition and physical activity on risk of Gestational Diabetes Mellitus in the nuMoM2b cohort
Kymberleigh A. Pagel#, Hoyin Chu#, Rashika Ramola, Rafael F. Guerrero, Judith H. Chung, Samuel Parry, Uma M. Reddy, Robert M. Silver, Jonathan G. Steller, Lynn M. Yee, Ronald J. Wapner, Matthew W. Hahn, Sriraam Natarajan, David M. Haas, Predrag Radivojac
JAMA Network Open  ·  Aug 2022
DOI

Co-author

Figure from “Population-scale sequencing resolves determinants of persistent EBV DNA”
Population-scale sequencing resolves determinants of persistent EBV DNA
Sherry S. Nyeo, Erin M. Cumming, Oliver S. Burren, Meghana S. Pagadala, Jacob C. Gutierrez, Thahmina A. Ali, Laura C. Kida, Yifan Chen, Hoyin Chu, Fengyuan Hu, Xueqing Zoe Zou, Benjamin Hollis, Margarete A. Fabre, Stewart MacArthur, Quanli Wang, Leif S. Ludwig, Kushal K. Dey, Slavé Petrovski, Ryan S. Dhindsa, Caleb A. Lareau
Nature  ·  Jan 2026
DOI
Figure from “Genomic correlates of clinical CAR-T cell activity”
Genomic correlates of clinical CAR-T cell activity
Mark B. Leick, Baihe Sun, Filippo Birocchi, Kathleen M. E. Gallagher, Alexandra Bratt, …, Hoyin Chu, …, Ali Hosseini Rad, Rhine R. Shen, Eliezer Van Allen, Saud AlDubayan, Marcela V. Maus
Science Immunology  ·  Jul 2026
DOI
Figure from “Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy”
Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy
Maria Caterina Rotiroti, Aidan M. Tousley, Hoyin Chu, Marco Herrera-Barrera, Antigoni Manousopoulou, Won-Ju Kim, Yajie Yin, Thomas Spencer Parish, Aniela Mitchell, Malcolm Holterhus, Lea Wenting Rysavy, Guillermo Nicolas Dalton, Katherine Ann Freitas, Gernot Kaber, Korbinian N. Kropp, Christopher A. Klebanoff, Ansuman T. Satpathy, Leo D. Wang, Caleb A. Lareau, Robbie G. Majzner
Nature Cancer  ·  Oct 2025
DOI
Figure from “Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling”
Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling
Alexandre Pellan Cheng, Adam J. Widman, Anushri Arora, Itai Rusinek, Aaron Sossin, …, Hoyin Chu, …, Michael A. Postow, Nicolas Robine, Bishoy M. Faltas, Genevieve Boland, Dan A. Landau
Nature Methods  ·  Apr 2025
DOI
Figure from “Nivolumab plus low-dose ipilimumab in hypermutated HER2-negative metastatic breast cancer: a phase II trial (NIMBUS)”
Nivolumab plus low-dose ipilimumab in hypermutated HER2-negative metastatic breast cancer: a phase II trial (NIMBUS)
Romualdo Barroso-Sousa, Jorge Gomez Tejeda Zanudo, Tianyu Li, Sangeetha M. Reddy, Leisha A. Emens, Thomas M. Kuntz, Carolina Alves Costa Silva, Saud H. AlDubayan, Hoyin Chu, Beth Overmoyer, Paulina Lange, Molly K. DiLullo, Meagan Montesion, Julie Kasparian, Melissa E. Hughes, Victoria Attaya, Ameer Basta, Nancy U. Lin, Nabihah Tayob, Rinath Jeselsohn, Elizabeth A. Mittendorf, Sara M. Tolaney
Nature Communications  ·  May 2025
DOI
Figure from “Integrative Analysis of Germline Rare Variants in Clear and Non–clear Cell Renal Cell Carcinoma”
Integrative Analysis of Germline Rare Variants in Clear and Non–clear Cell Renal Cell Carcinoma
Seung Hun Han, Sabrina Y. Camp, Hoyin Chu, Ryan Collins, Riaz Gillani, Jihye Park, Ziad Bakouny, Cora A. Ricker, Brendan Reardon, Nicholas Moore, Eric Kofman, Chris Labaki, David Braun, Toni K. Choueiri, Saud H. AlDubayan, Eliezer M. Van Allen
European Urology Open Science  ·  Apr 2024
DOI
Figure from “CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods”
CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods
The Critical Assessment of Genome Interpretation Consortium, Shantanu Jain, Constantina Bakolitsa, Steven E. Brenner, Predrag Radivojac, …, Hoyin Chu, …, Anne O’Donnell-Luria, Pauline C. Ng, John Shon, Joris Veltman, Justin M. Zook
Genome Biology  ·  Feb 2024
DOI
Figure from “Germline predisposition to pediatric Ewing sarcoma is characterized by inherited pathogenic variants in DNA damage repair genes”
Germline predisposition to pediatric Ewing sarcoma is characterized by inherited pathogenic variants in DNA damage repair genes
Riaz Gillani, Sabrina Y. Camp, Seunghun Han, Jill K. Jones, Hoyin Chu, Schuyler O’Brien, Erin L. Young, Lucy Hayes, Gareth Mitchell, Trent Fowler, Alexander Gusev, Junne Kamihara, Katherine A. Janeway, Joshua D. Schiffman, Brian D. Crompton, Saud H. AlDubayan, Eliezer M. Van Allen
The American Journal of Human Genetics  ·  Jun 2022
DOI

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Last update: 2026-09-10